Temporal pattern and synergy influence activity of ERK signaling pathways during L-LTP induction

Long-lasting long-term potentiation (L-LTP) is a cellular mechanism of learning and memory storage. Studies have demonstrated requirement for extracellular signal-regulated kinase (ERK) activation in L-LTP produced by diversity temporal stimulation patterns. Multiple signaling pathways converge to activate ERK, with different being required To answer whether how patterns select ERK activation, we developed computational model five (including two novel pathways) leading during induction. We show that calcium cAMP work synergistically stimuli given large intertrial intervals more than shorter intervals. Furthermore, these contribute dynamics activation. These results suggest sensitivities facilitate